Chemical Engineering


Manufacturing Facility for a Biopharmaceutical: Monoclonal Antibody

The goal of this project was to design a large-scale manufacturing facility that has the flexibility to produce a variety of Monoclonal Antibody (MAb) products, specifically the humanized MAb against Vascular Endothelial Growth Factor (VEGF), from Chinese hamster ovary (CHO) cells. Today monoclonal antibodies are being used to treat a variety of illnesses, such as rheumatoid arthritis, Crohn’s disease, transplant rejection,and a variety of cancers. It is important that the designed facility will allow the MAbs of today as well as the MAbs of tomorrow to be manufactured. The final design should include an economic analysis showing the profitability of this venture.

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